Addiction is a complex problem that requires more nuanced responses. Transforming Addiction advances addictions research and treatment by promoting transdisciplinary collaboration, the integration of sex and gender, and issues of trauma and mental health. The authors demonstrate these shifts and offer a range of tools, methods, and strategies for responding to the complex factors and forces that produce and shape addiction. In addition to providing practical examples of innovation from a range of perspectives, the contributors demonstrate how addiction spans biological, social, environmental, and economic realms. Transforming Addiction is a call to action, and represents some of the most provocative ways of thinking about addiction research, treatment, and policy in the contemporary era.